Matthew McConaughey lost a dramatic amount of weight to play cowboy Ron Woodroof in The Dallas Buyers Club, which also stars Jennifer Garner, and Jared Leto as a transsexual named Rayon.
Here's the film's synopsis from IMDB:
Loosely based on the true-life tale of Ron Woodroof, a drug taking, women loving, homophobic man who, in 1986 was diagnosed with full blown HIV/AIDS and given thirty days to live. He started taking the Food and Drug Administration (FDA) approved AZT, the only legal drug available in the U.S, which brought him to the brink of death. To survive, he smuggled non-toxic, anti-viral medications from all over the world, but yet still illegal in the U.S. Other AIDS patients sought out his medications forgoing hospitals, doctors and AZT. With the help of his Doctor, Eve Saks and a fellow patient, Rayon, Ron unintentionally created the Dallas Buyers Club, the first of dozens which would form around the country, providing its paying members with these alternative treatments. The clubs, growing in numbers and clientele, were brought to the attention of the FDA and pharmaceutical companies which waged an all out war on Ron. "DBC" follows Ron Woodroof's personal fight to survive which lasted 2191 days when he died on September 12, 1992, six years after he was diagnosed with the HIV virus.
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