Transgender Houseguest to Compete on ‘Big Brother’ for the First Time: VIDEO Andy Towle June 18, 2015 CBS' Big Brother has cast a transgender houseguest for the first time in the show's 17-season history. Audrey Middleton, a 25-year-old digital … [Read more...] about Transgender Houseguest to Compete on ‘Big Brother’ for the First Time: VIDEO